Elder Scrolls V: Skyrim is a big game. Really big. If you intend to play through many of the side quests and fully immerse yourself in Skyrim's game world, you could easily spend hundreds of hours wandering the different landscapes. To help you make the most out of that kind of time investment, Nvidia put together a lengthy tweak guide covering everything from basic configurations to obscure settings.
There's a lot to digest in the 20-page guide, and it's too bad reading through it doesn't level up an in-game skill or two. It does, however, go over all kinds of graphics settings, console commands, mod and graphics driver settings, and even advanced tweaking commands you can add to the initialization (.ini) files.