Thanks for the reply. Apparently I don't have my settings properly configured since I didn't get an e-mail when you posted ...
Anyway, this is for work, really. I'm actually running some code right now that's going to take 19.75 hrs (based on previous benchmarks). I'm running two instances of it, so it's using 2 cores, and each is occupying a 20.5GB VSIZE of RAM and varies between 17.5 and 20.3 RSIZE (I have 64 GB RAM). If I were to overclock my i7-3820 by just changing the CPU Strap to 125 MHz, then I could save 4 hours and then go on to the next image to run this code on.
The cooler I have is a Corsair H60, so I guess that would be classified as "intro liquid cooling"?
In terms of replacement frequency, I'm coming at this from a Mac side where I bought my first desktop for college in 2001, replaced the CPU in 2006, and replaced the tower in 2008. Still have that one as my main machine for non-work. Laptops replacement cycle for me was first in 2002, then 2005, then 2011. So I'm not really sure how quickly I plan on replacing the CPU in this, though since it's for work it'll be a tax write-off.
I was thinking maybe going with every-other Intel chip release, though I'll have to see what the benchmarks are when Intel comes out with their Ivy Bridge LGA 2011 chips in maybe a year.