I backed up my machine and installed it middle of last week.
No issues so I installed it on my CD burner box. The only issue had to do with having Alcohol 120% installed, didn't have the issue with my machine, but had seen it posted previously. Uninstalled Alcohol 120%, installed Service Pack 2, re-installed Alcohol 120%. I defragged the drives over the weekend and my FAT32 drive took forever, over 24 hours. Doesn't seem to be the drive, just the size. I'm doing a 150GB NTFS drive now and it is going about the same.
Backed up the wife's machine and installed, no issue. Installed on my son's machine, no issues. Installed on my work desktop, no issues. I'll install on my work laptop when I get the CD back or whenever it gets the update from Microsoft.
What are you using to defrag with. Even a heavily fragmented drive 120 gig takes only an hour here with Diskeeper 8 and SP2