I run both from time to time. Neither will catch everything, but it is better than nothing. Some of the "programs" that you are talking about might be more along the lines of a virus rather than spyware. What AV proggy are you using?
I use Norton AV, none of the spy ware checked out as viruses, but perhaps someone hacked/ disabled my spybot. Anything is possible I guess...
there is another spyware program called hijackthis but be very careful what you delete in this program. if you delete something that is not suppose to be deleted, it can mess up your comp.
Thank you for the tip
have you updated your Spybot?
I would always update it, and checked every week for anything new.